Datasets (28,460)

RNAseq of human buttock skin from healthy controls exposed to solar simulated radiation

RNAseq of human buttock skin from patients with solar urticaria exposed to solar simulated radiation

EuroSarc MEMOS mechanistic biomarker study in advanced osteosarcoma

Human intestinal stromal cells promote homeostasis in normal mucosa but inflammation in Crohn's disease in a retinoic acid-deficient manner

Multiple myeloma (MM) is the second most common hematological malignancy with poor outcome. Despite high sensitivity towards ubiquitin-proteasome-system (UPS) inhibitory therapies, the role of Deubiquitylases (DUBs) in MM pathophysiology and therapy has remained elusive. Starting from genetic screening for DUB dependencies in MM, we here identify OTUD6B as a central vulnerability in MM that drives the G1/S cell cycle transition by means of deubiquitylating and stabilizing LIN28B. RNA-Seq analyses reveal a significant downregulation of MYC target genes upon OTUD6B and LIN28B downregulation.

RNA-seq experiment to investigate the effect sulforaphane metabolism in HepG2 cells (human hepatocellular carcinoma cell lines). Cells treated with sulforaphane were compared against untreated cells in three different glucose environments: no glucose, basal and high glucose, to study the transcriptional effect of sulforaphane on liver cells at different metabolic states.

RNA-seq experiment to investigate the impact of sulforaphane metabolism in HepG2 cells. Cells with NRF2 knockdown treated with sulforaphane were compared to untreated cells with NRF2 knock-down. Similarly, wild type cells treated with sulforaphane were compared to untreated cells.

Peripheral blood genetic signature of severe cirrhosis in HIV/HCV coinfected patients

RNA Seq of control and IRGM KD HT-29 Cells infected with Salmonella typhimurium

RNA-seq of BRAF-wildtype and BRAF-V600E_knock-in healthy colon organoids

RNA-seq of FOXQ1-transfected HCT116 cells to understand the Wnt-dependent and independent FOXQ1 transcriptional output in colorectal cancers.

Multi-omics characterization of the monkeypox virus infection

The regulation of transcriptome in HCC cells by SRSF10 [Huh7_shSRSF10_RNAseq]

Lineage-Specific Mesenchymal Stromal Cells Derived from Human iPSCs Showed Distinct Patterns in Transcriptomic Profile and Extracellular Vesicle Production

Molecular profiling of pre-and post-5-azacytidine myelodysplastic syndrome samples identifies predictors of response